A23187
\ˌe͡ɪ twˈɛntiθɹˈiː θˈa͡ʊzənd wˈɒnhˈʌndɹədən ˈe͡ɪtisˈɛvən], \ˌeɪ twˈɛntiθɹˈiː θˈaʊzənd wˈɒnhˈʌndɹədən ˈeɪtisˈɛvən], \ˌeɪ t_w_ˈɛ_n_t_i_θ_ɹ_ˈiː θ_ˈaʊ_z_ə_n_d_ w_ˈɒ_n_h_ˈʌ_n_d_ɹ_ə_d_ə_n ˈeɪ_t_i_s_ˈɛ_v_ə_n]\
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An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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