HOMOLOGOUS RESTRICTION FACTOR 20
\həmˈɒləɡəs ɹɪstɹˈɪkʃən fˈaktə twˈɛnti], \həmˈɒləɡəs ɹɪstɹˈɪkʃən fˈaktə twˈɛnti], \h_ə_m_ˈɒ_l_ə_ɡ_ə_s ɹ_ɪ_s_t_ɹ_ˈɪ_k_ʃ_ə_n f_ˈa_k_t_ə t_w_ˈɛ_n_t_i]\
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Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.