ABL ONCOGENES
\ˈabə͡l ˈɒnkə͡ʊd͡ʒˌiːnz], \ˈabəl ˈɒnkəʊdʒˌiːnz], \ˈa_b_əl ˈɒ_n_k_əʊ_dʒ_ˌiː_n_z]\
Sort: Oldest first
-
Retrovirus-associated DNA sequences (abl) originally isolated from the Abelson murine leukemia virus (Ab-MuLV). The proto-oncogene abl (c-abl) codes for a protein that is a member of the tyrosine kinase family. The human c-abl gene is located at 9q34.1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.