SEVERE INFANTILE MYOCLONIC EPILEPSY
\sɪvˈi͡əɹ ˈɪnfəntˌa͡ɪl mˌa͡ɪəklˈɒnɪk ˈɛpɪlˌɛpsi], \sɪvˈiəɹ ˈɪnfəntˌaɪl mˌaɪəklˈɒnɪk ˈɛpɪlˌɛpsi], \s_ɪ_v_ˈiə_ɹ ˈɪ_n_f_ə_n_t_ˌaɪ_l m_ˌaɪ_ə_k_l_ˈɒ_n_ɪ_k ˈɛ_p_ɪ_l_ˌɛ_p_s_i]\
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A clinically diverse group of epilepsy syndromes characterized either by myoclonic seizures or by myoclonus in association with other seizure types. Myoclonic epilepsy syndromes are divided into three subtypes based on etiology: familial, cryptogenic, and symptomatic (i.e., occurring secondary to known disease processes such as infections, hypoxic-ischemic injuries, trauma, etc.).
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.