SEVERE COMBINED IMMUNODEFICIENT MICE
\sɪvˈi͡ə kəmbˈa͡ɪnd ɪmjˈuːnə͡ʊdfˌɪʃənt mˈa͡ɪs], \sɪvˈiə kəmbˈaɪnd ɪmjˈuːnəʊdfˌɪʃənt mˈaɪs], \s_ɪ_v_ˈiə k_ə_m_b_ˈaɪ_n_d ɪ_m_j_ˈuː_n_əʊ_d_f_ˌɪ_ʃ_ə_n_t m_ˈaɪ_s]\
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Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
Nearby Words
- severe acute respiratory syndrome
- severe combined immunodeficiencies
- severe combined immunodeficiency
- severe combined immunodeficiency disease
- severe combined immunodeficiency syndrome
- Severe Combined Immunodeficient Mice
- severe combined immunologic deficiency
- severe infantile myoclonic epilepsy
- severed
- severely
- severeness