TONIC CLONIC CONVULSION DISORDER
\tˈɒnɪk klˈɒnɪk kənvˈʌlʃən dɪsˈɔːdə], \tˈɒnɪk klˈɒnɪk kənvˈʌlʃən dɪsˈɔːdə], \t_ˈɒ_n_ɪ_k k_l_ˈɒ_n_ɪ_k k_ə_n_v_ˈʌ_l_ʃ_ə_n d_ɪ_s_ˈɔː_d_ə]\
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A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
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Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.