SYNDROME OF CONTINUOUS MUSCLE ACTIVITY
\sˈɪndɹə͡ʊm ɒv kəntˈɪnjuːəs mˈʌsə͡l aktˈɪvɪti], \sˈɪndɹəʊm ɒv kəntˈɪnjuːəs mˈʌsəl aktˈɪvɪti], \s_ˈɪ_n_d_ɹ_əʊ_m ɒ_v k_ə_n_t_ˈɪ_n_j_uː_ə_s m_ˈʌ_s_əl a_k_t_ˈɪ_v_ɪ_t_i]\
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A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)
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