RUPTURED INTERVERTEBRAL DISC
\ɹˈʌpt͡ʃəd ˌɪntəvˈɜːtɪbɹə͡l dˈɪsk], \ɹˈʌptʃəd ˌɪntəvˈɜːtɪbɹəl dˈɪsk], \ɹ_ˈʌ_p_tʃ_ə_d ˌɪ_n_t_ə_v_ˈɜː_t_ɪ_b_ɹ_əl d_ˈɪ_s_k]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.