RECEPTORS, INSULIN LIKE GROWTH FACTOR I
\ɹɪsˈɛptəz], \ɹɪsˈɛptəz], \ɹ_ɪ_s_ˈɛ_p_t_ə_z]\
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A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precusor protein. The beta subunit contains an intrisic tyrosine kinase domain. EC 2.7.11.-.
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