QUISQUALATE RECEPTOR
\kwˈɪskwəlˌe͡ɪt ɹɪsˈɛptə], \kwˈɪskwəlˌeɪt ɹɪsˈɛptə], \k_w_ˈɪ_s_k_w_ə_l_ˌeɪ_t ɹ_ɪ_s_ˈɛ_p_t_ə]\
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Cell surface proteins that bind glutamate and directly gate ion channels in cell membranes. AMPA receptors were originally discriminated from other glutamate receptors by their affinity for the agonist AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid). They are probably the most common mediators of fast excitatory synaptic transmission in the central nervous system. Several subtypes have been cloned, and for some types the traditional distinction from kainate receptors may not apply.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.