PILCZ-WESTPHAL PHENOMENON

\pˈɪlkzwˈɛstfə͡l fɪnˈɒmɪnən], \pˈɪlkzwˈɛstfə‍l fɪnˈɒmɪnən], \p_ˈɪ_l_k_z_w_ˈɛ_s_t_f_əl f_ɪ_n_ˈɒ_m_ɪ_n_ə_n]\

Definitions of PILCZ-WESTPHAL PHENOMENON

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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