GUNTHERS DISEASE
\ɡˈʌnθəz dɪzˈiːz], \ɡˈʌnθəz dɪzˈiːz], \ɡ_ˈʌ_n_θ_ə_z d_ɪ_z_ˈiː_z]\
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Autosomal recessive porphyria characterized by splenomegaly, photosensitivity, hemolytic anemia, and the appearance of red urine in early infancy. This condition results from increased synthesis of uroporphyrinogen I relative to uroporphyrinogen III in bone marrow normoblasts.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.