FALCIPARUM MALARIA
\fˈalsɪpˌɑːɹəm malˈe͡əɹi͡ə], \fˈalsɪpˌɑːɹəm malˈeəɹiə], \f_ˈa_l_s_ɪ_p_ˌɑː_ɹ_ə_m m_a_l_ˈeə_ɹ_iə]\
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Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.