CONTRAVALLATION

\kˌɒntɹəvalˈe͡ɪʃən], \kˌɒntɹəvalˈe‍ɪʃən], \k_ˌɒ_n_t_ɹ_ə_v_a_l_ˈeɪ_ʃ_ə_n]\
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1894 - The Clarendon dictionary
By William Hand Browne, Samuel Stehman Haldeman
 
1871 - The Cabinet Dictionary of the English Language
 
1790 - A Complete Dictionary of the English Language
By Thomas Sheridan

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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