CLOVEN SPINE
\klˈə͡ʊvən spˈa͡ɪn], \klˈəʊvən spˈaɪn], \k_l_ˈəʊ_v_ə_n s_p_ˈaɪ_n]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.