CENTRAL ALVEOLAR HYPOVENTILATION
\sˈɛntɹə͡l ˌalvɪˈə͡ʊlə hˌa͡ɪpə͡ʊvˌɛntɪlˈe͡ɪʃən], \sˈɛntɹəl ˌalvɪˈəʊlə hˌaɪpəʊvˌɛntɪlˈeɪʃən], \s_ˈɛ_n_t_ɹ_əl ˌa_l_v_ɪ__ˈəʊ_l_ə h_ˌaɪ_p_əʊ_v_ˌɛ_n_t_ɪ_l_ˈeɪ_ʃ_ə_n]\
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A condition associated with multiple episodes of sleep apnea which are distinguished from obstructive sleep apnea (SLEEP APNEA, OBSTRUCTIVE) by the complete cessation of efforts to breathe. This disorder is associated with dysfunction of central nervous system centers that regulate respiration. This condition may be idiopathic (primary) or associated with lower brain stem lesions; chronic obstructive pulmonary disease (LUNG DISEASES, OBSTRUCTIVE); HEART FAILURE, CONGESTIVE; medication effect; and other conditions. Sleep maintenance is impaired, resulting in daytime hypersomnolence. Primary central sleep apnea is frequently associated with obstructive sleep apnea. When both forms are present the condition is referred to as mixed sleep apnea (see SLEEP APNEA SYNDROMES). (Adams et al., Principles of Neurology, 6th ed, p395; Neurol Clin 1996;14 (3):611-28)
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Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.