TRANSCORTICAL APRAXIA
\tɹanskˈɔːtɪkə͡l ɐpɹˈe͡ɪksi͡ə], \tɹanskˈɔːtɪkəl ɐpɹˈeɪksiə], \t_ɹ_a_n_s_k_ˈɔː_t_ɪ_k_əl ɐ_p_ɹ_ˈeɪ_k_s_iə]\
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A form of APRAXIA characterized by an acquired inability to carry out a complex motor activity despite the ability to mentally formulate the action. This condition has been attributed to a disruption of connections between the dominant parietal cortex and supplementary and premotor cortical regions in both hemispheres. (From Adams et al., Principles of Neurology, 6th ed, p57)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.