RU486
\ɹˈuː fˈɔːhˈʌndɹədən ˈe͡ɪtisˈɪks], \ɹˈuː fˈɔːhˈʌndɹədən ˈeɪtisˈɪks], \ɹ_ˈuː f_ˈɔː_h_ˈʌ_n_d_ɹ_ə_d_ə_n ˈeɪ_t_i_s_ˈɪ_k_s]\
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A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
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