RETROGRADE DEGENERATION
\ɹˌɛtɹə͡ʊɡɹˈe͡ɪd dɪd͡ʒˌɛnəɹˈe͡ɪʃən], \ɹˌɛtɹəʊɡɹˈeɪd dɪdʒˌɛnəɹˈeɪʃən], \ɹ_ˌɛ_t_ɹ_əʊ_ɡ_ɹ_ˈeɪ_d d_ɪ_dʒ_ˌɛ_n_ə_ɹ_ˈeɪ_ʃ_ə_n]\
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Pathologic changes that occur in the axon and cell body of a neuron proximal to an axonal lesion. The process is characterized by central chromatolysis which features flattening and displacement of the nucleus, loss of Nissl bodies, and cellular edema. Central chromatolysis primarily occurs in lower motor neurons.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.