MACROTYN
\mˈakɹətˌɪn], \mˈakɹətˌɪn], \m_ˈa_k_ɹ_ə_t_ˌɪ_n]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.