JOSEF KALOUSEK

\d͡ʒˈə͡ʊsəf kˈala͡ʊsˌɛk], \d‍ʒˈə‍ʊsəf kˈala‍ʊsˌɛk], \dʒ_ˈəʊ_s_ə_f k_ˈa_l_aʊ_s_ˌɛ_k]\
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1910 - Warner's dictionary of authors ancient and modern
By Charles Dudley Warner

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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