HOLLAND PATENT

\hˈɒlənd pˈe͡ɪtənt], \hˈɒlənd pˈe‍ɪtənt], \h_ˈɒ_l_ə_n_d p_ˈeɪ_t_ə_n_t]\

Definitions of HOLLAND PATENT

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1894 - Dictionary of United States history
By John Franklin Jameson

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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