ENDO A CYTOKERATIN
\ˈɛndə͡ʊ ɐ sˈa͡ɪtə͡ʊkɹˌatɪn], \ˈɛndəʊ ɐ sˈaɪtəʊkɹˌatɪn], \ˈɛ_n_d_əʊ ɐ s_ˈaɪ_t_əʊ_k_ɹ_ˌa_t_ɪ_n]\
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A class of fibrous proteins or scleroproteins important both as structural proteins and as keys to the study of protein conformation. The family represents the principal constituent of epidermis, hair, nails, horny tissues, and the organic matrix of tooth enamel. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms an alpha-helix, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.