EDITH NEWBOLD JONES WHARTON
\ˈiːdɪθ njˈuːbə͡ʊld d͡ʒˈə͡ʊnz wˈɔːtən], \ˈiːdɪθ njˈuːbəʊld dʒˈəʊnz wˈɔːtən], \ˈiː_d_ɪ_θ n_j_ˈuː_b_əʊ_l_d dʒ_ˈəʊ_n_z w_ˈɔː_t_ə_n]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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