DISTAL MEDIAL NEUROPATHIES
\dɪstˈal mˈiːdiːəl njuːɹˈɒpəθɪz], \dɪstˈal mˈiːdiːəl njuːɹˈɒpəθɪz], \d_ɪ_s_t_ˈa_l m_ˈiː_d_iː__ə_l n_j_uː_ɹ_ˈɒ_p_ə_θ_ɪ_z]\
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Disease involving the median nerve, from its origin at the BRACHIAL PLEXUS to its termination in the hand. Clinical features include weakness of wrist and finger flexion, forearm pronation, thenar abduction, and loss of sensation over the lateral palm, first three fingers, and radial half of the ring finger. Common sites of injury include the elbow, where the nerve passes through the two heads of the pronator teres muscle (pronator syndrome) and in the carpal tunnel (CARPAL TUNNEL SYNDROME).
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.