DISINTEGRINS
\dˌɪsɪntˈɛɡɹɪnz], \dˌɪsɪntˈɛɡɹɪnz], \d_ˌɪ_s_ɪ_n_t_ˈɛ_ɡ_ɹ_ɪ_n_z]\
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A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
By DataStellar Co., Ltd
Word of the day
Snake's-head
- Guinea-hen flower; -- so called in England because its spotted petals resemble the scales of a snake's head.