CLOSELY-HELD
\klˈə͡ʊslɪhˈɛld], \klˈəʊslɪhˈɛld], \k_l_ˈəʊ_s_l_ɪ_h_ˈɛ_l_d]\
Definitions of CLOSELY-HELD
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.