BURGHART'S SIGN

\bˈɜːɡɑːts sˈa͡ɪn], \bˈɜːɡɑːts sˈa‍ɪn], \b_ˈɜː_ɡ_ɑː_t_s s_ˈaɪ_n]\

Definitions of BURGHART'S SIGN

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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